6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈 ,AR,98%
Chir99021
| 别名: | 6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑2基)嘧啶2-ylamino]乙基氨基]吡啶-3-腈;6-[[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)-2-嘧啶]氨基]乙基]氨基]-3-吡啶甲腈;6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基];6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈;CHIR-99021 (CT99021) HCl (free base) 抑制剂;CHIR-99021 (CT99021) 抑制剂;抑制剂CHIR-99021;6-[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基]氨基]乙氨基]吡啶-3-腈 | ||
|---|---|---|---|
| Cas号: | 252917-06-9 | 物化性质: | |
| 分子式: | C22H18Cl2N8 | 熔点: | |
| 分子量: | 465.3379 | 沸点: | |
| EINECS编号: | 密度: | ||
| MDL号: | 储存条件: | ||
中文名称：6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈
CAS号：252917-06-9
中文别名：6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑2基)嘧啶2-ylamino]乙基氨基]吡啶-3-腈;6-[[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)-2-嘧啶]氨基]乙基]氨基]-3-吡啶甲腈;6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基];6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈;CHIR-99021 (CT99021) HCl (free base) 抑制剂;CHIR-99021 (CT99021) 抑制剂;抑制剂CHIR-99021;6-[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基]氨基]乙氨基]吡啶-3-腈
英文名称：Chir-99021
分子式：C22H18CL2N8
分子量：465.3379
纯度：98%
沸点：784.1±70.0°C(Predicted)
密度：1.48
储存条件：-20°C
溶解度：DMSO:soluble2mg/mL,clear(warmed)
酸度系数：(pKa)11.92±0.10(Predicted)
形态：powderChemicalbook
颜色：whitetolightbrown
稳定性：Stablefor2yearsfromdateofpurchaseassupplied.SolutionsinDMSOmaybestoredat-20°forupto3months.
体外研究：CHIR-99021inhibitshumanGSK-3βwithKivaluesof9.8nM.CHIR-99021isasmallorganicmoleculethatinhibitsGSK3αandGSK3βbycompetingfortheirATP-bindingsites.InvitrokinaseassaysrevealthatCHIR-99021specificallyinhibitsGChemicalbookSK3β(IC50=~5nM)andGSK3α(IC50=~10nM),withlittleeffectonotherkinases.InthepresenceofCHIR-99021theviabilityoftheES-D3cellsisreducedby24.7%at2.5μM,56.3%at5μM,61.9%at7.5μMand69.2%at10μMCHIR-99021withanIC50of4.9μM.
CAS号：252917-06-9
中文别名：6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑2基)嘧啶2-ylamino]乙基氨基]吡啶-3-腈;6-[[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)-2-嘧啶]氨基]乙基]氨基]-3-吡啶甲腈;6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基];6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈;CHIR-99021 (CT99021) HCl (free base) 抑制剂;CHIR-99021 (CT99021) 抑制剂;抑制剂CHIR-99021;6-[2-[[4-(2,4-二氯苯基)-5-(5-甲基-1H-咪唑-2-基)嘧啶-2-基]氨基]乙氨基]吡啶-3-腈
英文名称：Chir-99021
分子式：C22H18CL2N8
分子量：465.3379
纯度：98%
沸点：784.1±70.0°C(Predicted)
密度：1.48
储存条件：-20°C
溶解度：DMSO:soluble2mg/mL,clear(warmed)
酸度系数：(pKa)11.92±0.10(Predicted)
形态：powderChemicalbook
颜色：whitetolightbrown
稳定性：Stablefor2yearsfromdateofpurchaseassupplied.SolutionsinDMSOmaybestoredat-20°forupto3months.
体外研究：CHIR-99021inhibitshumanGSK-3βwithKivaluesof9.8nM.CHIR-99021isasmallorganicmoleculethatinhibitsGSK3αandGSK3βbycompetingfortheirATP-bindingsites.InvitrokinaseassaysrevealthatCHIR-99021specificallyinhibitsGChemicalbookSK3β(IC50=~5nM)andGSK3α(IC50=~10nM),withlittleeffectonotherkinases.InthepresenceofCHIR-99021theviabilityoftheES-D3cellsisreducedby24.7%at2.5μM,56.3%at5μM,61.9%at7.5μMand69.2%at10μMCHIR-99021withanIC50of4.9μM.
搜索质检报告(COA)
搜索MSDS
6-[2-[4-(2,4-二氯苯基)-5-(4-甲基-1H-咪唑-2-基)嘧啶-2-基氨基]乙基氨基]吡啶-3-甲腈
6-[2-[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino]ethylamino]pyridine-3-carbonitrile;6-{2-[4-(2,4-Dichloro-phenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile;CHIR-99021;CT99021;3-Pyridinecarbonitrile, 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-;4-(4-formyl-3-methoxyphenoxy)butanoicacid;6-(2-(4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-ylamino)ethylamino)nicotinonitrile;6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile;CHIR 99021;CHIR99021 (CHIR-99021, CT 99021);CHIR-99021 (CT99021);CHIR-99021 (CT99021) HCl;CHIR-99021 Hydrochloride;3-PYRIDINECARBONITRILE,6-[[2-[[4-(2,4-DICHLOROPHENYL)-5-(5-METHYL-1H-IMIDAZOL-2-YL)-2-PYRIMIDINYL]AMINO]ETHYL]AMINO];CT-99021;6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile;GSK-3 Inhibitor XVI;CHIR99021;CT 99021;6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile;234CMT4GK4;6-[(2-{[4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino}ethyl)amino]pyridine-3-carbonitrile;A
